(2R,3R)-2-[(4-Chlorophenyl)hydroxymethyl]cyclopentanone
نویسندگان
چکیده
The title compound, C(12)H(13)ClO(2), was prepared by the direct asymmetric inter-molecular aldol reaction of cyclo-penta-none and 4-chloro-benzaldehyde catalysed by l-tryptophan in water. The absolute mol-ecular structure was determined to be a racemic twin with 91% (2R,3R) isomer and 9% of the (2S,3S) form. In the crystal structure, the mol-ecules are connected into a one-dimensional chain along the a axis through the formation of inter-molecular O-H⋯O hydrogen bonds. Further, non-conventional C-H⋯O and C-H⋯π contacts are observed in the structure, which consolidate the crystal packing.
منابع مشابه
(2R,3R)-N-(4-Chlorophenyl)-2,3-dihydroxy-N′-(5-phenyl-1,3,4-thiadiazol-2-yl)succinamide
In the structure of the title compound, C(18)H(15)ClN(4)O(4)S, the dihedral angle between the two benzene rings is 1.4 (3)°. The angle between the phenyl ring and thia-diazole ring is 5.8 (4)°. The conformations of the N-H and C=O bonds are anti with respect to each other. In the crystal structure, mol-ecules are linked by inter-molecular O-H⋯N, N-H⋯O and O-H⋯O hydrogen bonds, forming a three-d...
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The title compound, C(25)H(24)ClNO(3), has three contiguous chiral centres. The absolute structure was determined by anomalous dispersion. The chloro-benzene ring is inclined to the two phenyl rings by 14.98 (9) and 59.05 (9)°. The two phenyl rings are inclined to one another by 49.51 (10)°. In the crystal, neighbouring mol-ecules are linked via C-H⋯O hydrogen bonds, forming chains propagating ...
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The crystal structure of the title compound, C(6)H(11)NO(5), establishes the relative configuration at the four stereogenic centres; the absolute configuration is determined by the use of d-glucuronolactone as the starting material for the synthesis. Mol-ecules are linked by inter-molecular O-H⋯O and N-H⋯O hydrogen bonds into a three-dimensional network, with each mol-ecule acting as a donor an...
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